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KMID : 0043320060290110990
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Archives of Pharmacal Research
2006 Volume.29 No. 11 p.990 ~ p.997
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Studies on Cardio-suppressant, Vasodilator and Tracheal Relaxant Effects of Sarcococca saligna
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Ghayur Muhammad Nabeel
Gilani Anwarul Hassan
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Abstract
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Sarcococca saligna is a shrub that is traditionally used for its medicinal properties in Pakistan. In this study we report the cardio-suppressant, vasodilator and tracheal relaxant activities of the aqueous-methanolic extract (Ss.Cr) of the plant. Ss.Cr, that tested positive for the presence of saponins, flavonoids, tannins, phenols, and alkaloids, exhibited a dose-dependent (0.3-5 mg/mL) negative inotropic and chronotropic effect on the isolated guinea-pig atrium which was resistant to atropine () and aminophylline () pretreatment. In rabbit thoracic aorta, Ss.Cr dose-dependently (0.1-3 mg/mL) relaxed the high (80 mM) and phenylephrine ()-induced contractions, indicating a possible channel blocking (CCB) effect. When tested against PE () control peaks in normal -free Kreb’s solution, Ss.Cr exhibited dose-dependent (0.1-3 mg/mL) inhibition, being more potent in relaxing the PE responses in -free Kreb’s solution, thus indicating specific blockade of release from the intracellular stores. Ss.Cr also relaxed the agonist-induced contractions in: a) rat aorta irrespective of the presence of endothelium or nitric oxide synthase inhibitor L-NAME and b) rabbit and guinea-pig tracheal strips. The data shows that Ss.Cr possesses possible channel blocking activity which might be responsible for its observed cardio-suppressant, vasodilator and tracheal relaxant effects though more tests are required to confirm this channel blocking effect.
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KEYWORD
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Sarcococca saligna, Intracellular release inhibitor, Cardio-suppressant, Vasodilator, Tracheal relaxant
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